טוען...
Instructive roles for agonist binding parameters in determining the functional bandwidth of cytokine receptor signaling
The affinity of cytokine-receptor complexes on the cell surface is often poorly predictive of functional potency. To address this conundrum, we explored the inter-relationships of receptor binding to a wide range of downstream functional metrics for a prototypical cytokine, Interleukin-13 (IL-13), t...
שמור ב:
| הוצא לאור ב: | Sci Signal |
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| Main Authors: | , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568809/ https://ncbi.nlm.nih.gov/pubmed/26554818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab2677 |
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