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Instructive roles for agonist binding parameters in determining the functional bandwidth of cytokine receptor signaling
The affinity of cytokine-receptor complexes on the cell surface is often poorly predictive of functional potency. To address this conundrum, we explored the inter-relationships of receptor binding to a wide range of downstream functional metrics for a prototypical cytokine, Interleukin-13 (IL-13), t...
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| 發表在: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568809/ https://ncbi.nlm.nih.gov/pubmed/26554818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aab2677 |
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