Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer

Oncogenic gene fusions drive many human cancers, but tools to more quickly unravel their functional contributions are needed. Here we describe methodology permitting fusion gene construction for functional evaluation. Using this strategy, we engineered the known fusion oncogenes, BCR-ABL1, EML4-ALK,...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lu, Hengyu, Villafane, Nicole, Dogruluk, Turgut, Grzeskowiak, Caitlin L., Kong, Kathleen, Tsang, Yiu Huen, Zagorodna, Oksana, Pantazi, Angeliki, Yang, Lixing, Neill, Nicholas J., Kim, Young Won, Creighton, Chad J., Verhaak, Roel G., Mills, Gordon B., Park, Peter, Kucherlapati, Raju, Scott, Kenneth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568774/
https://ncbi.nlm.nih.gov/pubmed/28512244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2745
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