Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations

Large-scale sequencing efforts are uncovering the complexity of cancer genomes, which are comprised of causal “driver” mutations that promote tumor progression along with many more pathologically-neutral “passenger” events. The majority of mutations, both in known cancer drivers and uncharacterized...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Dogruluk, Turgut, Tsang, Yiu Huen, Espitia, Maribel, Chen, Fengju, Chen, Tenghui, Chong, Zechen, Appadurai, Vivek, Dogruluk, Armel, Eterovic, Agna Karina, Bonnen, Penelope E., Creighton, Chad J., Chen, Ken, Mills, Gordon B., Scott, Kenneth L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681596/
https://ncbi.nlm.nih.gov/pubmed/26627007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1654
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