PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment(1,2). Recent studies have shown that increases in neuronal activity play an important role in glioblastoma...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Yu, Kwanha, Lin, Chia-Ching John, Hatcher, Asante, Lozzi, Brittney, Kong, Kathleen, Huang-Hobbs, Emmet, Cheng, Yi-Ting, Beechar, Vivek B, Zhu, Wenyi, Zhang, Yiqun, Chen, Fengju, Mills, Gordon B, Mohila, Carrie A, Creighton, Chad J, Noebels, Jeffrey L, Scott, Kenneth L, Deneen, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577741/
https://ncbi.nlm.nih.gov/pubmed/31996845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-1952-2
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