PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment(1,2). Recent studies have shown that increases in neuronal activity play an important role in glioblastoma...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Yu, Kwanha, Lin, Chia-Ching John, Hatcher, Asante, Lozzi, Brittney, Kong, Kathleen, Huang-Hobbs, Emmet, Cheng, Yi-Ting, Beechar, Vivek B, Zhu, Wenyi, Zhang, Yiqun, Chen, Fengju, Mills, Gordon B, Mohila, Carrie A, Creighton, Chad J, Noebels, Jeffrey L, Scott, Kenneth L, Deneen, Benjamin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577741/
https://ncbi.nlm.nih.gov/pubmed/31996845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-1952-2
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