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Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

The final step in the biosynthesis of the antibiotic chloramphenicol is the oxidation of an aryl-amine substrate to an aryl-nitro product catalyzed by the N-oxygenase CmlI in three two-electron steps. The CmlI active site contains a diiron cluster ligated by three histidine and four glutamate residu...

詳細記述

保存先:
書誌詳細
出版年:J Am Chem Soc
主要な著者: Jasniewski, Andrew J., Komor, Anna J., Lipscomb, John D., Que, Lawrence
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568637/
https://ncbi.nlm.nih.gov/pubmed/28673082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05389
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