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Mechanism for Six-Electron Aryl-N-oxygenation by the Non-Heme Diiron Enzyme CmlI
The ultimate step in chloramphenicol (CAM) biosynthesis is a six-electron oxidation of an aryl-amine precursor (NH(2)-CAM) to the aryl-nitro group of CAM catalyzed by the non-heme diiron cluster-containing oxygenase CmlI. Upon exposure of the diferrous cluster to O(2), CmlI forms a long-lived peroxo...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914076/ https://ncbi.nlm.nih.gov/pubmed/27203126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b03341 |
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