Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

Prion diseases are infectious neurodegenerative disorders of humans and animals caused by misfolded forms of the cellular prion protein PrP(C). Prions cause disease by converting PrP(C) into aggregation-prone PrP(Sc). Chronic wasting disease (CWD) is the most contagious prion disease with substantia...

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Udgivet i:PLoS Pathog
Main Authors: Hannaoui, Samia, Amidian, Sara, Cheng, Yo Ching, Duque Velásquez, Camilo, Dorosh, Lyudmyla, Law, Sampson, Telling, Glenn, Stepanova, Maria, McKenzie, Debbie, Wille, Holger, Gilch, Sabine
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568445/
https://ncbi.nlm.nih.gov/pubmed/28800624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006553
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