Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

Prion diseases are infectious neurodegenerative disorders of humans and animals caused by misfolded forms of the cellular prion protein PrP(C). Prions cause disease by converting PrP(C) into aggregation-prone PrP(Sc). Chronic wasting disease (CWD) is the most contagious prion disease with substantia...

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Publicado en:PLoS Pathog
Main Authors: Hannaoui, Samia, Amidian, Sara, Cheng, Yo Ching, Duque Velásquez, Camilo, Dorosh, Lyudmyla, Law, Sampson, Telling, Glenn, Stepanova, Maria, McKenzie, Debbie, Wille, Holger, Gilch, Sabine
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568445/
https://ncbi.nlm.nih.gov/pubmed/28800624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006553
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