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Site-directed mutagenesis of the human adenosine A(2A) receptor. Critical involvement of Glu(13) in agonist recognition

A glutamic acid residue in the first transmembrane domain of the human adenosine A(2A) receptor was mutated to glutamine. Radioligand binding studies on COS-7 cell membranes expressing either the wild-type or the mutant receptor revealed that the affinity of the prototypic agonist CGS21680 (2-[4-[(2...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Pharmacol
Prif Awduron: IJzerman, Ad P., Von Frijtag Drabbe Künzel, Jacobien K., Kim, Jeongho, Jiang, Qiaoling, Jacobson, Kenneth A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567773/
https://ncbi.nlm.nih.gov/pubmed/10927024
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