In vivo Endocrine Secretion of Prostacyclin Following Expression of a Cyclooxygenase-1/Prostacyclin Fusion Protein in the Salivary Glands of Rats Via Nonviral Gene Therapy

Pulmonary arterial hypertension (PAH) is a progressive disease that culminates in right heart failure and death. Prostacyclin (PGI2) and its derivatives are effective treatments for PAH when administered as continuous parenteral infusions. This treatment paradigm requires medical sophistication, and...

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Опубликовано в: :Hum Gene Ther
Главные авторы: Wang, Zhimin, Benza, Raymond L., Zourelias, Lee, Sanguino, Angela, Geguchadze, Ramaz, Shields, Kelly J., Wu, Changgong, Highland, Kristin B., Passineau, Michael J.
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc. 2017
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567413/
https://ncbi.nlm.nih.gov/pubmed/28530128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.040
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