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IL-17 sequestration via salivary gland gene therapy in a mouse model of Sjogren’s syndrome suppresses disease-associated expression of the putative autoantigen Klk1b22

INTRODUCTION: IL-17 has a putative role in the pathophysiology of Sjogren’s syndrome (SS) and has been shown to be upregulated in the salivary glands of affected individuals. Sequestration of IL-17 with Adenoviral-mediated gene therapy has previously shown a benefit upon the SS-like phenotype in the...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Wu, Changgong, Wang, Zhimin, Zourelias, Lee, Thakker, Hiteshi, Passineau, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527205/
https://ncbi.nlm.nih.gov/pubmed/26245278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0714-2
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