In vivo Endocrine Secretion of Prostacyclin Following Expression of a Cyclooxygenase-1/Prostacyclin Fusion Protein in the Salivary Glands of Rats Via Nonviral Gene Therapy

Pulmonary arterial hypertension (PAH) is a progressive disease that culminates in right heart failure and death. Prostacyclin (PGI2) and its derivatives are effective treatments for PAH when administered as continuous parenteral infusions. This treatment paradigm requires medical sophistication, and...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Wang, Zhimin, Benza, Raymond L., Zourelias, Lee, Sanguino, Angela, Geguchadze, Ramaz, Shields, Kelly J., Wu, Changgong, Highland, Kristin B., Passineau, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567413/
https://ncbi.nlm.nih.gov/pubmed/28530128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.040
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