DNA damage tolerance in hematopoietic stem and progenitor cells in mice

DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage related to fork stalling. Three modes of DDT have been documented: translesion synthesis (TLS), template switching (TS), and repriming. TLS a...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul, Lancini, Cesare, Song, Ji-Ying, Citterio, Elisabetta, Jacobs, Heinz
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5565453/
https://ncbi.nlm.nih.gov/pubmed/28761001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706508114
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