Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification by deubiquitinating enzymes (DUBs) impacts genome maintenance in vivo is largely unknown. To address this question, we generated mice deficien...

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Библиографические подробности
Главные авторы: Lancini, Cesare, van den Berk, Paul C.M., Vissers, Joseph H.A., Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144738/
https://ncbi.nlm.nih.gov/pubmed/25113974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131436
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