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Polycomb and lung cancer: When the dosage makes the (kind of) poison

The Polycomb transcriptional repressors regulate normal tissue homeostasis and their function is often hijacked during oncogenesis. We recently uncovered the Polycomb repressive complex-2 (PRC2) genes Ezh2 and Eed as oncogenotype-dependent cancer genes. Notably, within the same oncogenotype, PRC2 do...

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Publicado en:Mol Cell Oncol
Main Authors: Gargiulo, Gaetano, Citterio, Elisabetta, Serresi, Michela
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909420/
https://ncbi.nlm.nih.gov/pubmed/27314096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1152345
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