Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state

The IL-2/IL-2R pathway is implicated in type 1 diabetes (T1D). While its role in regulatory T cell (Treg) biology is well characterized, mechanisms that influence IL-2 responses in effector T cells (Teff) are less well understood. We compared IL-2 responses in 95 healthy control and 98 T1D subjects....

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Publicado no:Clin Immunol
Main Authors: Schwedhelm, Katharine, Thorpe, Jerill, Murray, Sara A., Gavin, Marc, Speake, Cate, Greenbaum, Carla, Cerosaletti, Karen, Buckner, Jane, Long, S. Alice
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564451/
https://ncbi.nlm.nih.gov/pubmed/28645874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.06.004
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