Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4(+)CD25(+) Regulatory T-Cells of Type 1 Diabetic Subjects

OBJECTIVE: In humans, multiple genes in the interleukin (IL)-2/IL-2 receptor (IL-2R) pathway are associated with type 1 diabetes. However, no link between IL-2 responsiveness and CD4(+)CD25(+)FOXP3(+) regulatory T-cells (Tregs) has been demonstrated in type 1 diabetic subjects despite the role of th...

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Autores principales: Long, S. Alice, Cerosaletti, Karen, Bollyky, Paul L., Tatum, Megan, Shilling, Heather, Zhang, Sheng, Zhang, Zhong-Yin, Pihoker, Catherine, Sanda, Srinath, Greenbaum, Carla, Buckner, Jane H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809970/
https://ncbi.nlm.nih.gov/pubmed/19875613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0694
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