Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4(+)CD25(hi) T Cells of Type 1 Diabetic and Multiple Sclerosis Patients

IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4(+)CD25(hi)FOXP3(+) regulatory T cells (Treg); a cell type that plays an integral role in maintaining tolerance. Thus, we hypothesized that decreased response to IL-2 may be a common phenotype of subjects who have...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Cerosaletti, Karen, Schneider, Anya, Schwedhelm, Katharine, Frank, Ian, Tatum, Megan, Wei, Shan, Whalen, Elizabeth, Greenbaum, Carla, Kita, Mariko, Buckner, Jane, Long, S. Alice
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871703/
https://ncbi.nlm.nih.gov/pubmed/24376757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083811
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker