Circulating Integrin Alpha4/Beta7+ Lymphocytes Targeted by Vedolizumab Have a Pro-Inflammatory Phenotype

Integrin alpha4/beta7 on circulating lymphocytes identifies them as gut-tropic, and can be targeted by the humanized antibody vedolizumab to treat inflammatory bowel disease (IBD). We found lymphocytes expressing alpha4/beta7 were significantly more responsive to the pro-inflammatory cytokines IL-6,...

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Detaylı Bibliyografya
Yayımlandı:Clin Immunol
Asıl Yazarlar: Lord, James D., Long, S. Alice, Shows, Donna M., Thorpe, Jerill, Schwedhelm, Katherine, Chen, Janice, Kita, Mariko, Buckner, Jane H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257989/
https://ncbi.nlm.nih.gov/pubmed/29842945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2018.05.006
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