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The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.

Because monoclonal antibodies (mAbs) directed against alpha4-integrin and VCAM-1 inhibit the development of experimental autoimmune encephalomyelitis (EAE) in vivo, it has been concluded that the successful therapeutic effect is due to interference with alpha4beta1/VCAM-1-mediated interaction of aut...

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Detalhes bibliográficos
Main Authors: Engelhardt, B, Laschinger, M, Schulz, M, Samulowitz, U, Vestweber, D, Hoch, G
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509164/
https://ncbi.nlm.nih.gov/pubmed/9854045
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