Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

Interleukin-6 (IL-6) is a key pathogenic cytokine in multiple autoimmune diseases including rheumatoid arthritis and multiple sclerosis, suggesting that dysregulation of the IL-6 pathway may be a common feature of autoimmunity. The role of IL-6 in type 1 diabetes (T1D) is not well understood. We sho...

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Publicado en:Sci Transl Med
Main Authors: Hundhausen, Christian, Roth, Alena, Whalen, Elizabeth, Chen, Janice, Schneider, Anya, Long, S. Alice, Wei, Shan, Rawlings, Rebecca, Kinsman, MacKenzie, Evanko, Stephen P., Wight, Thomas N., Greenbaum, Carla J., Cerosaletti, Karen, Buckner, Jane H.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125295/
https://ncbi.nlm.nih.gov/pubmed/27629486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad9943
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