Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants

While many phenotypes have been associated with variants in human leukocyte antigen (HLA) genes, the full phenotypic impact of HLA variants across all diseases is unknown. We imputed HLA genomic variation from two populations of 28,839 and 8,431 European ancestry individuals and tested association o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Transl Med
Hauptverfasser: Karnes, Jason H, Bastarache, Lisa, Shaffer, Christian M, Gaudieri, Silvana, Xu, Yaomin, Glazer, Andrew, Mosley, Jonathan D, Zhao, Shilin, Raychaudhuri, Soumya, Mallal, Simon, Ye, Zhan, Mayer, John G, Brilliant, Murray H, Hebbring, Scott J, Roden, Dan M, Phillips, Elizabeth J, Denny, Joshua C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563969/
https://ncbi.nlm.nih.gov/pubmed/28490672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai8708
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge