Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants

While many phenotypes have been associated with variants in human leukocyte antigen (HLA) genes, the full phenotypic impact of HLA variants across all diseases is unknown. We imputed HLA genomic variation from two populations of 28,839 and 8,431 European ancestry individuals and tested association o...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Karnes, Jason H, Bastarache, Lisa, Shaffer, Christian M, Gaudieri, Silvana, Xu, Yaomin, Glazer, Andrew, Mosley, Jonathan D, Zhao, Shilin, Raychaudhuri, Soumya, Mallal, Simon, Ye, Zhan, Mayer, John G, Brilliant, Murray H, Hebbring, Scott J, Roden, Dan M, Phillips, Elizabeth J, Denny, Joshua C
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563969/
https://ncbi.nlm.nih.gov/pubmed/28490672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai8708
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