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Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

Here we report the structural characterization of the product formed from the reaction between hydroethidine (HE) and superoxide ([Formula: see text]). By using mass spectral and NMR techniques, the chemical structure of this product was determined as 2-hydroxyethidium (2-OH-E(+)). By using an authe...

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Detalhes bibliográficos
Main Authors: Zhao, Hongtao, Joseph, Joy, Fales, Henry M., Sokoloski, Edward A., Levine, Rodney L., Vasquez-Vivar, Jeannette, Kalyanaraman, B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC556312/
https://ncbi.nlm.nih.gov/pubmed/15824309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501719102
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