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Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung
High-molecular-mass polyethylenimines (PEIs) are widely used vectors for nucleic acid delivery. We found that removal of the residual N-acyl moieties from commercial linear 25-kDa PEI enhanced its plasmid DNA delivery efficiency 21 times in vitro, as well as 10,000 times in mice with a concomitant 1...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556302/ https://ncbi.nlm.nih.gov/pubmed/15824322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502067102 |
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