Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice

Successful propagation of HIV in the human host requires entry into a permissive cell, reverse transcription of viral RNA, integration into the human genome, transcription of the integrated provirus, and assembly/release of new virus particles. Currently, there are antiretrovirals against each of th...

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Publicat a:PLoS One
Autors principals: Medina-Moreno, Sandra, Dowling, Thomas C., Zapata, Juan C., Le, Nhut M., Sausville, Edward, Bryant, Joseph, Redfield, Robert R., Heredia, Alonso
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560554/
https://ncbi.nlm.nih.gov/pubmed/28817720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183425
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