Activation of P-TEFb at Sites of Dual HIV/TB Infection, and Inhibition of MTB-Induced HIV Transcriptional Activation by the Inhibitor of CDK9, Indirubin-3′-Monoxime

At sites of Mycobacterium tuberculosis (MTB) infection, HIV-1 replication is increased during tuberculosis (TB). Here we investigated the role of positive transcription elongation factor (P-TEFb), comprised of CycT1 and CDK9, as the cellular cofactor of HIV-1 Tat protein in transcriptional activatio...

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Autores principales: Toossi, Zahra, Wu, Mianda, Hirsch, Christina S., Mayanja-Kizza, Harriet, Baseke, Joy, Aung, Htin, Canaday, David H., Fujinaga, Koh
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
Materias:
Pathogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275925/
https://ncbi.nlm.nih.gov/pubmed/21453127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2010.0211
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