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Dose- and time-dependent α-synuclein aggregation induced by ferric iron in SK-N-SH cells

OBJECTIVE: Intracellular formation of Lewy body (LB) is one of the hallmarks of Parkinson’s disease. The main component of LB is aggregated α-synuclein, present in the substantia nigra where iron accumulation also occurs. The present study was aimed to study the relationship between iron and α-synuc...

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Bibliografiske detaljer
Udgivet i:Neurosci Bull
Main Authors: Li, Wen-Jing, Jiang, Hong, Song, Ning, Xie, Jun-Xia
Format: Artigo
Sprog:Inglês
Udgivet: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560295/
https://ncbi.nlm.nih.gov/pubmed/20502498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-010-1117-7
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