Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas

Constitutive B-cell receptor signaling leads to overexpression of the anti-apoptotic BCL-2 protein and is implicated in the pathogenesis of many types of B-cell Non-Hodgkin Lymphoma (B-NHL). The BCL-2 small molecule inhibitor venetoclax shows promising clinical response rates in several lymphomas, b...

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Pubblicato in:Cancer Res
Autori principali: O’Steen, Shyril, Green, Damian J., Gopal, Ajay K., Orozco, Johnnie J., Kenoyer, Aimee L., Lin, Yukang, Wilbur, D. Scott, Hamlin, Donald K., Fisher, Darrell R., Hylarides, Mark D., Gooley, Theodore A., Waltman, Amelia, Till, Brian G., Press, Oliver W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560265/
https://ncbi.nlm.nih.gov/pubmed/28566329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0082
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