Venetoclax Synergizes with Radiotherapy for Treatment of B-cell Lymphomas

Constitutive B-cell receptor signaling leads to overexpression of the anti-apoptotic BCL-2 protein and is implicated in the pathogenesis of many types of B-cell Non-Hodgkin Lymphoma (B-NHL). The BCL-2 small molecule inhibitor venetoclax shows promising clinical response rates in several lymphomas, b...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: O’Steen, Shyril, Green, Damian J., Gopal, Ajay K., Orozco, Johnnie J., Kenoyer, Aimee L., Lin, Yukang, Wilbur, D. Scott, Hamlin, Donald K., Fisher, Darrell R., Hylarides, Mark D., Gooley, Theodore A., Waltman, Amelia, Till, Brian G., Press, Oliver W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560265/
https://ncbi.nlm.nih.gov/pubmed/28566329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0082
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