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Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
BACKGROUND: The interferon (IFN)-induced, dsRNA-dependent serine/threonine protein kinase, PKR, plays a key regulatory role in the IFN-mediated anti-viral response by blocking translation in the infected cell by phosphorylating the alpha subunit of elongation factor 2 (eIF2). The human immunodeficie...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC556014/ https://ncbi.nlm.nih.gov/pubmed/15737233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-2-17 |
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