Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer

PURPOSE: Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer (PCa) outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo SLCO-mediated transport and that SLCO...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Clin Cancer Res
المؤلفون الرئيسيون: Mostaghel, Elahe A, Cho, Eunpi, Zhang, Ailin, Alyamani, Mohammad, Kaipainen, Arja, Green, Sean, Marck, Brett T, Sharifi, Nima, Wright, Jonathan L, Gulati, Roman, True, Lawrence D, Loda, Massimo, Matsumoto, Alvin M, Tamae, Daniel, Penning, Trevor M, Balk, Steven P, Kantoff, Phillip W, Nelson, Peter S, Taplin, Mary-Ellen, Montgomery, R Bruce
التنسيق: Artigo
اللغة:Inglês
منشور في: 2017
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559332/
https://ncbi.nlm.nih.gov/pubmed/28389510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2245
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