Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer

PURPOSE: Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer (PCa) outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo SLCO-mediated transport and that SLCO...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Mostaghel, Elahe A, Cho, Eunpi, Zhang, Ailin, Alyamani, Mohammad, Kaipainen, Arja, Green, Sean, Marck, Brett T, Sharifi, Nima, Wright, Jonathan L, Gulati, Roman, True, Lawrence D, Loda, Massimo, Matsumoto, Alvin M, Tamae, Daniel, Penning, Trevor M, Balk, Steven P, Kantoff, Phillip W, Nelson, Peter S, Taplin, Mary-Ellen, Montgomery, R Bruce
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559332/
https://ncbi.nlm.nih.gov/pubmed/28389510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2245
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires