Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer

PURPOSE: Germline variation in solute carrier organic anion (SLCO) genes influences cellular steroid uptake and is associated with prostate cancer (PCa) outcomes. We hypothesized that, due to its steroidal structure, the CYP17A inhibitor abiraterone may undergo SLCO-mediated transport and that SLCO...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Mostaghel, Elahe A, Cho, Eunpi, Zhang, Ailin, Alyamani, Mohammad, Kaipainen, Arja, Green, Sean, Marck, Brett T, Sharifi, Nima, Wright, Jonathan L, Gulati, Roman, True, Lawrence D, Loda, Massimo, Matsumoto, Alvin M, Tamae, Daniel, Penning, Trevor M, Balk, Steven P, Kantoff, Phillip W, Nelson, Peter S, Taplin, Mary-Ellen, Montgomery, R Bruce
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559332/
https://ncbi.nlm.nih.gov/pubmed/28389510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2245
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