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Redirecting abiraterone metabolism to fine tune prostate cancer anti-androgen therapy
Abiraterone blocks androgen synthesis and prolongs survival in castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis(1,2). Abiraterone is metabolized in patients to D4A, which has even greater anti-tumor activity and structural similarities to endogenous...
Guardat en:
| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5111629/ https://ncbi.nlm.nih.gov/pubmed/27225130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17954 |
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