Redirecting abiraterone metabolism to fine tune prostate cancer anti-androgen therapy

Abiraterone blocks androgen synthesis and prolongs survival in castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis(1,2). Abiraterone is metabolized in patients to D4A, which has even greater anti-tumor activity and structural similarities to endogenous...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature
Hauptverfasser: Li, Zhenfei, Alyamani, Mohammad, Li, Jianneng, Rogacki, Kevin, Abazeed, Mohamed, Upadhyay, Sunil K., Balk, Steven P., Taplin, Mary-Ellen, Auchus, Richard J., Sharifi, Nima
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111629/
https://ncbi.nlm.nih.gov/pubmed/27225130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17954
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge