Redirecting abiraterone metabolism to fine tune prostate cancer anti-androgen therapy

Abiraterone blocks androgen synthesis and prolongs survival in castration-resistant prostate cancer, which is otherwise driven by intratumoral androgen synthesis(1,2). Abiraterone is metabolized in patients to D4A, which has even greater anti-tumor activity and structural similarities to endogenous...

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Udgivet i:Nature
Main Authors: Li, Zhenfei, Alyamani, Mohammad, Li, Jianneng, Rogacki, Kevin, Abazeed, Mohamed, Upadhyay, Sunil K., Balk, Steven P., Taplin, Mary-Ellen, Auchus, Richard J., Sharifi, Nima
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111629/
https://ncbi.nlm.nih.gov/pubmed/27225130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17954
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