ABIRATERONE ACETATE TREATMENT LOWERS 11-OXYGENATED ANDROGENS

CONTEXT: The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1),...

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Udgivet i:Eur J Endocrinol
Main Authors: Wright, Connor, O’Day, Patrick, Alyamani, Mohammed, Sharifi, Nima, Auchus, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096060/
https://ncbi.nlm.nih.gov/pubmed/32045360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-19-0905
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