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Steroidogenic metabolism of galeterone reveals a diversity of biochemical activities
Galeterone is a steroidal CYP17A1 inhibitor, androgen receptor (AR) antagonist and AR degrader, and was under evaluation in a phase III clinical trial for castration-resistant prostate cancer (CRPC). The A/B steroid ring (Δ(5), 3β-hydroxyl) structure of galeterone is identical to cholesterol, which...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5533090/ https://ncbi.nlm.nih.gov/pubmed/28648378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.05.020 |
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