The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer

Prostate cancer is the second leading cause of cancer death in the United States. Treatment of localized high-risk disease and de novo metastatic disease frequently leads to relapse. These metastatic castration resistant prostate cancers (mCRPC) claim a high mortality rate, despite the extended surv...

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Pubblicato in:Chem Biol Interact
Autori principali: Tamae, Daniel, Mostaghel, Elahe, Montgomery, Bruce, Nelson, Peter S., Balk, Steven P., Kantoff, Philip W., Taplin, Mary-Ellen, Penning, Trevor M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414681/
https://ncbi.nlm.nih.gov/pubmed/25514466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2014.12.012
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