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11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): implications for castration resistant prostate cancer.
The progression of castration resistant prostate cancer (CRPC) is driven by the intratumoral conversion of adrenal androgen precursors to potent androgens. The expression of aldo- keto reductase 1C3 (AKR1C3), which catalyses the reduction of weak androgens to more potent androgens, is significantly...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Steroid Biochem Mol Biol |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6283102/ https://ncbi.nlm.nih.gov/pubmed/29936123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2018.06.013 |
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