11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): implications for castration resistant prostate cancer.

The progression of castration resistant prostate cancer (CRPC) is driven by the intratumoral conversion of adrenal androgen precursors to potent androgens. The expression of aldo- keto reductase 1C3 (AKR1C3), which catalyses the reduction of weak androgens to more potent androgens, is significantly...

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Publicado en:J Steroid Biochem Mol Biol
Main Authors: Barnard, Monique, Quanson, Jonathan L., Mostaghel, Elahe, Pretorius, Elzette, Snoep, Jacky L., Storbeck, Karl-Heinz
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283102/
https://ncbi.nlm.nih.gov/pubmed/29936123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2018.06.013
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