11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): implications for castration resistant prostate cancer.

The progression of castration resistant prostate cancer (CRPC) is driven by the intratumoral conversion of adrenal androgen precursors to potent androgens. The expression of aldo- keto reductase 1C3 (AKR1C3), which catalyses the reduction of weak androgens to more potent androgens, is significantly...

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Bibliografske podrobnosti
izdano v:J Steroid Biochem Mol Biol
Main Authors: Barnard, Monique, Quanson, Jonathan L., Mostaghel, Elahe, Pretorius, Elzette, Snoep, Jacky L., Storbeck, Karl-Heinz
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283102/
https://ncbi.nlm.nih.gov/pubmed/29936123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2018.06.013
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