11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): implications for castration resistant prostate cancer.

The progression of castration resistant prostate cancer (CRPC) is driven by the intratumoral conversion of adrenal androgen precursors to potent androgens. The expression of aldo- keto reductase 1C3 (AKR1C3), which catalyses the reduction of weak androgens to more potent androgens, is significantly...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Steroid Biochem Mol Biol
Prif Awduron: Barnard, Monique, Quanson, Jonathan L., Mostaghel, Elahe, Pretorius, Elzette, Snoep, Jacky L., Storbeck, Karl-Heinz
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283102/
https://ncbi.nlm.nih.gov/pubmed/29936123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2018.06.013
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