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SUMOylation determines the voltage required to activate cardiac I(Ks) channels
I(Ks) channels open in response to depolarization of the membrane voltage during the cardiac action potential, passing potassium ions outward to repolarize ventricular myocytes and end each beat. Here, we show that the voltage required to activate I(Ks) channels depends on their covalent modificatio...
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| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5559042/ https://ncbi.nlm.nih.gov/pubmed/28743749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706267114 |
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