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I(Ks) ion-channel pore conductance can result from individual voltage sensor movements

The I(Ks) current has an established role in cardiac action potential repolarization, and provides a repolarization reserve at times of stress. The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together gate the I(Ks)...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Westhoff, Maartje, Eldstrom, Jodene, Murray, Christopher I., Thompson, Emely, Fedida, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475427/
https://ncbi.nlm.nih.gov/pubmed/30918124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811623116
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