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I(Ks) ion-channel pore conductance can result from individual voltage sensor movements

The I(Ks) current has an established role in cardiac action potential repolarization, and provides a repolarization reserve at times of stress. The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together gate the I(Ks)...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Westhoff, Maartje, Eldstrom, Jodene, Murray, Christopher I., Thompson, Emely, Fedida, David
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475427/
https://ncbi.nlm.nih.gov/pubmed/30918124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811623116
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