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I(Ks) ion-channel pore conductance can result from individual voltage sensor movements

The I(Ks) current has an established role in cardiac action potential repolarization, and provides a repolarization reserve at times of stress. The underlying channels are formed from tetramers of KCNQ1 along with one to four KCNE1 accessory subunits, but how these components together gate the I(Ks)...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Westhoff, Maartje, Eldstrom, Jodene, Murray, Christopher I., Thompson, Emely, Fedida, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6475427/
https://ncbi.nlm.nih.gov/pubmed/30918124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811623116
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