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The I(Ks) Channel Response to cAMP Is Modulated by the KCNE1:KCNQ1 Stoichiometry

The delayed potassium rectifier current, I(Ks,) is assembled from tetramers of KCNQ1 and varying numbers of KCNE1 accessory subunits in addition to calmodulin. This channel complex is important in the response of the cardiac action potential to sympathetic stimulation, during which I(Ks) is enhanced...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Thompson, Emely, Eldstrom, Jodene, Westhoff, Maartje, McAfee, Donald, Fedida, David
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224683/
https://ncbi.nlm.nih.gov/pubmed/30314657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.09.018
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