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Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of Na(V)1.5 Channels
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (I(LATE)) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of Na(V)1.5 channels so they reopen when normally inactive, late in the action potential. Na(V)1.5 is SUMOylated o...
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| Publicat a: | Cell Rep |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7054841/ https://ncbi.nlm.nih.gov/pubmed/32075761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.025 |
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