I(Ks) channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits

Human I(Ks) channels activate slowly with the onset of cardiac action potentials to repolarize the myocardium. I(Ks) channels are composed of KCNQ1 (Q1) pore-forming subunits that carry S4 voltage-sensor segments and KCNE1 (E1) accessory subunits. Together, Q1 and E1 subunits recapitulate the conduc...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ruscic, Katarina J., Miceli, Francesco, Villalba-Galea, Carlos A., Dai, Hui, Mishina, Yukiko, Bezanilla, Francisco, Goldstein, Steve A. N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2013
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574954/
https://ncbi.nlm.nih.gov/pubmed/23359697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222616110
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