Dynamic Partnership between KCNQ1 and KCNE1 and Influence on Cardiac I(Ks) Current Amplitude by KCNE2

Cardiac slow delayed rectifier (I(Ks)) channel is composed of KCNQ1 (pore-forming) and KCNE1 (auxiliary) subunits. Although KCNE1 is an obligate I(Ks) component that confers the uniquely slow gating kinetics, KCNE2 is also expressed in human heart. In vitro experiments suggest that KCNE2 can associa...

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Detalhes bibliográficos
Main Authors: Jiang, Min, Xu, Xulin, Wang, Yuhong, Toyoda, Futoshi, Liu, Xian-Sheng, Zhang, Mei, Robinson, Richard B., Tseng, Gea-Ny
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713561/
https://ncbi.nlm.nih.gov/pubmed/19372218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808262200
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