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Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the I(Ks) Amplitude in Check until when Larger I(Ks) Is Needed
BACKGROUND: KCNQ1 and KCNE1 assemble to form the slow delayed rectifier (I(Ks)) channel critical for shortening ventricular action potentials during high β-adrenergic tone. However, too much I(Ks) under basal conditions poses an arrhythmogenic risk. Our objective is to understand how adult ventricul...
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| Published in: | Circ Arrhythm Electrophysiol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5535779/ https://ncbi.nlm.nih.gov/pubmed/28611207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005084 |
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