Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Eosinophils and the release of cationic granule proteins have long been implicated in the development of the type 2–induced pathologies linked with respiratory inflammation. Paradoxically, the ablation of the two genes encoding the most abundant of these granule proteins, major basic protein-1 (MBP-...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Ochkur, Sergei I., Doyle, Alfred D., Jacobsen, Elizabeth A., LeSuer, William E., Li, Wen, Protheroe, Cheryl A., Zellner, Katie R., Colbert, Dana, Shen, HuaHao H., Irvin, Charlie G., Lee, James J., Lee, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2017
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557640/
https://ncbi.nlm.nih.gov/pubmed/28515227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3HI1116-488RR
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