HIF is not essential for suppression of experimental tumor growth by mTOR inhibition

The Hypoxia Inducible Transcription Factor (HIF) is the master regulator of cellular response to hypoxic adaptation. Solid tumors inevitably harbour hypoxic regions with subsequent stabilization and activation of HIF and HIF target genes due to poor vascularization and rapid growth. The mammalian ta...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cancer
Main Authors: Knaup, Karl X., Guenther, Regina, Stoeckert, Johanna, Monti, Juliana M., Eckardt, Kai-Uwe, Wiesener, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556644/
https://ncbi.nlm.nih.gov/pubmed/28819378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.16486
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